Thermo Fisher Scientific CD80 Monoclonal Antibody (MEM-233), Alexa Fluor 700

Applications

• Flow Cytometry (Flow): 4 µL / 1×10⁶ cells

Product Specifications

Additional Formats

• Unconjugated (MA1-19215)
• APC (MA1-19464)
• FITC (MA1-19590)
• PE (MA1-10288)
• PerCP (MA1-10289)
• Custom conjugation available upon request

Product Specific Information

This antibody reacts with an extracellular epitope of CD80 (B7-1), a 60 kDa single-chain type I glycoprotein of the immunoglobulin superfamily. It is expressed on professional antigen-presenting cells such as dendritic cells, macrophages, and activated B lymphocytes.

Target Information

CD80 (B7-1) and CD86 (B7-2) are ligands of the T-cell costimulatory molecule CD28 and the inhibitory receptor CTLA-4 (CD152). Both B7 molecules are essential for T-cell activation and can substitute for each other in this process.
CD80 is rapidly induced on the surface of activated B cells, EBV-transformed B cell lines, Burkitt’s lymphoma cells, follicular B lymphoma cells, T cells, and monocytes.
B7-1 provides regulatory signals for T lymphocytes through binding to CD28 and CTLA-4.
Diseases associated with CD80 dysfunction include gallbladder squamous cell carcinoma and myocarditis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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