Thermo Fisher Scientific CD80 Monoclonal Antibody (MEM-233), Alexa Fluor 700
인간 CD80(B7-1) 항원을 인식하는 Mouse IgG1 단클론 항체로, Alexa Fluor 700 형광으로 표지됨. Flow Cytometry에 적합하며, 세포 표면 CD80 발현 분석에 유용. PBS/BSA 완충액에 보존되며 4°C 암소 보관.
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Applications
- Flow Cytometry (Flow): 4 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-233 |
| Immunogen | Extracellular domain of human CD80 fused to human IgG1 (Fc) |
| Conjugate | Alexa Fluor™ 700 |
| Excitation / Emission Max | 696 / 719 nm |
| Form | Liquid |
| Concentration | Not Determined |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898659 |
Additional Formats
- Unconjugated (MA1-19215)
- APC (MA1-19464)
- FITC (MA1-19590)
- PE (MA1-10288)
- PerCP (MA1-10289)
- Custom conjugation available upon request
Product Specific Information
This antibody reacts with an extracellular epitope of CD80 (B7-1), a 60 kDa single-chain type I glycoprotein of the immunoglobulin superfamily. It is expressed on professional antigen-presenting cells such as dendritic cells, macrophages, and activated B lymphocytes.
Target Information
CD80 (B7-1) and CD86 (B7-2) are ligands of the T-cell costimulatory molecule CD28 and the inhibitory receptor CTLA-4 (CD152). Both B7 molecules are essential for T-cell activation and can substitute for each other in this process.
CD80 is rapidly induced on the surface of activated B cells, EBV-transformed B cell lines, Burkitt’s lymphoma cells, follicular B lymphoma cells, T cells, and monocytes.
B7-1 provides regulatory signals for T lymphocytes through binding to CD28 and CTLA-4.
Diseases associated with CD80 dysfunction include gallbladder squamous cell carcinoma and myocarditis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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