Thermo Fisher Scientific CD56 (NCAM) Monoclonal Antibody (TULY56), PE, eBioscience

Thermo Fisher Scientific CD56 (NCAM) Monoclonal Antibody (TULY56), PE, eBioscience™

Applications and Tested Dilution

• Application: Flow Cytometry (Flow)
• Tested Dilution: 5 µL (0.06 µg)/test
• Publications: View 11 publications

Product Specifications

Available Conjugate Formats

• Alexa Fluor 660, 700
• APC, APC-eFluor 780
• Brilliant UV 395–805
• Brilliant Violet 421–786
• eFluor 450, 506
• FITC
• NovaFluor Blue, Red, Yellow series
• PE-Cyanine5, PE-Cyanine7, PE-eFluor 610
• PerCP-eFluor 710
• Super Bright 436–780
• Request custom conjugation

Product Specific Information

This TULY56 monoclonal antibody reacts with human CD56 (Neural Cell Adhesion Molecule, NCAM). CD56 is a highly glycosylated transmembrane molecule expressed by neurons, mediating homotypic neural cell adhesion.
In hematopoietic cells, CD56 is expressed on NK cells and NKT cells. Staining with TULY56 does not block CMSSB binding, indicating recognition of different epitopes. TULY56 performs better after fixation and permeabilization than CMSSB and crossreacts with Rhesus macaque.

Applications Reported: Flow cytometric analysis
Applications Tested: Pre-titrated and tested on normal human peripheral blood cells.
Recommended use at 5 µL (0.06 µg) per test (100 µL final volume, 10⁵–10⁸ cells/test).
Excitation: 488–561 nm; Emission: 578 nm
Laser Compatibility: Blue, Green, Yellow-Green Laser
Filtration: 0.2 µm post-manufacturing filtered

Target Information

CD56 (NCAM) is a transmembrane glycoprotein of the immunoglobulin family functioning as an adhesive molecule. Expressed throughout the nervous system (isoforms 120–180 kDa), it is found on T cells and NK cells, involved in migration, axonal growth, pathfinding, and synaptic plasticity.
Polysialic modification reduces CD56-mediated adhesion. Through its extracellular region, CD56 binds laminin and integrins, mediating homophilic and heterophilic interactions.
CD56 is expressed in neuroectodermal-derived lines and neoplasms such as retinoblastoma, medulloblastoma, astrocytoma, and neuroblastoma. It serves as a sensitive neuroendocrine marker for neuroendocrine and ovarian granulosa cell tumors.
Diseases associated with CD56 dysfunction include rabies and blastic plasmacytoid dendritic cell neoplasms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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