Thermo Fisher Scientific IL1A Monoclonal Antibody (OTI3C3), TrueMAB
IL1A 단백질을 표적으로 하는 마우스 단일클론 항체로, WB, IHC, ICC/IF에 사용 가능. TrueMAB 포맷으로 고순도 액상 형태 제공. 인간 IL1A 전장 재조합 단백질을 면역원으로 사용. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3C3 |
| Immunogen | Full length human recombinant IL1A protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
IL-1 alpha (Interleukin-1 alpha) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is encoded by the IL1A gene and signals through two receptors, IL-1RI and IL-1RII, shared with IL-1 beta.
Located on chromosome 2q13, IL-1 alpha plays a key role in innate host defense by inducing other proinflammatory cytokines and initiating acute-phase responses.
Its activity is regulated by IL-1 Receptor Antagonist (IL-1RA), which blocks receptor binding via competitive inhibition. IL-1 alpha influences NF-kappaB and MAPK pathways, stimulates IL6 and COX-2 expression, and enhances nitric oxide production.
Elevated IL-1 alpha levels are associated with chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, and multiple sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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