Thermo Fisher Scientific IL1A Monoclonal Antibody (OTI3A5), TrueMAB
IL1A 단백질을 표적으로 하는 Mouse IgG1 단클론 항체로, Western Blot 및 Immunocytochemistry에 적합합니다. TrueMAB 형식으로 높은 특이성과 재현성을 제공하며, 액상 형태로 1 mg/mL 농도입니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3A5 |
| Immunogen | Full length human recombinant IL1A protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
IL-1 alpha (Interleukin-1 alpha) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is encoded by the IL1A gene and signals through IL-1RI and IL-1RII receptors, shared with IL-1 beta.
IL1A is located on chromosome 2q13 and plays a crucial role in innate host defense by inducing other proinflammatory cytokines and acute-phase responses.
IL-1RA acts as a competitive inhibitor to moderate IL-1 alpha activity. This cytokine is involved in immune responses, inflammation, and hematopoiesis.
Produced as a proprotein by monocytes and macrophages, IL-1 alpha is processed and released upon cell injury to induce apoptosis.
It also regulates NF-kappaB and MAP kinase activities, stimulates IL6 and COX-2 expression, and enhances nitric oxide production.
Elevated IL-1 alpha levels are associated with chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, and multiple sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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