Thermo Fisher Scientific NOTCH2 Chimeric Recombinant Mouse Monoclonal Antibody (B9)
NOTCH2 단백질을 인식하는 마우스 유래 키메릭 재조합 단클론 항체. 인간 및 마우스 시료에 반응하며, ICC/IF, ELISA, 억제 분석 등에 사용 가능. Protein A로 정제된 액상 항체로, 1 mg/mL 농도. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunocytochemistry (ICC/IF) | Assay-dependent | - |
| ELISA | Assay-dependent | - |
| Inhibition Assays (IA) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | B9 |
| Immunogen | NRR of mouse Notch 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074268 |
Product Specific Information
Specificity: An engineered ScFv fragment antibody that binds to both mouse mNRR2 and human hNRR2 but not NRR1.
Target Information
Neurogenic locus notch homolog protein 2 (NOTCH2) is a highly conserved Notch signaling pathway protein. NOTCH2 is a type I transmembrane protein with an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain composed of multiple domain types.
It functions as a receptor for membrane-bound ligands Jagged1, Jagged2, and Delta1 to regulate cell-fate determination.
Defects in NOTCH2 are associated with Alagille syndrome type 2 (ALGS2), an autosomal dominant multisystem disorder characterized by hepatic bile duct paucity, cholestasis, and additional cardiac, skeletal, and ophthalmologic manifestations.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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