Thermo Fisher Scientific PAI1 Monoclonal Antibody (242816)
인간 PAI1 단백질을 인식하는 mouse IgG1 단일클론 항체로, WB, ELISA, Neutralization에 사용 가능. 높은 특이성과 재현성을 제공하며, Protein A/G 정제 및 Lyophilized 형태로 제공. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| ELISA (Detection) | 0.1–0.4 µg/mL |
| ELISA (Capture) | 2–8 µg/mL |
| Neutralization (Neu) | 0.3 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 242816 |
| Immunogen | Sf21-derived recombinant human Serpin E1/PAI-1 (Met1–Pro402) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2609712 |
Product Specific Information
- In direct ELISAs, no cross-reactivity with recombinant human Serpin A1, A3, A4, A8, C1, F1, F2, I1, I2, recombinant mouse Serpin D1 or E2 is observed.
- Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
PAI1 (plasminogen activator inhibitor 1) belongs to the serine protease inhibitor superfamily and is the principal inhibitor of tissue-type and urokinase-type plasminogen activators (tPA and uPA). Platelets are the main source of circulating PAI1, but it is also synthesized and secreted by fibroblasts, smooth muscle cells, endothelial cells, hepatocytes, and inflammatory cells.
Expression of PAI1 can be regulated by various factors including growth factors, cytokines, hormones, inflammatory mediators, metabolic products, and environmental stimuli. Elevated PAI1 levels are associated with thrombosis, obesity, thrombophilia, and metabolic syndrome. Defects in PAI1 lead to abnormal bleeding and are linked to plasminogen activator inhibitor-1 deficiency. PAI1 mediates inhibition of fibrinolysis and may promote neuronal survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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