Thermo Fisher Scientific TWEAK Monoclonal Antibody (173830)

Applications

Tested Dilution

Publications

ELISA (ELISA)

0.1-0.4 µg/mL (Detection), 2-8 µg/mL (Capture)

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

173830

Immunogen

E. coli-derived recombinant human TWEAK/TNFSF12 Arg93-His249 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TWEAK,uniProtId:O43508-1,ncbiNodeId:9606,antigenRange:93-249,antigenLength:249,antigenImageFileName:MA5-23783_TWEAK_O43508-1_House_mouse.svg,antigenImageFileNamePDP:MA5-23783_TWEAK_O43508-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5 mg/mL

Purification

Protein A/G

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2610267

Product Specific Information

In sandwich ELISAs, approximately 15% reactivity with recombinant mouse TWEAK is observed and no cross-reactivity with recombinant human (rh) BAFF, rhEDA-A2, rhLIGHT, rhFas Ligand, rhGITR Ligand, rhLT alpha 1 beta 2, rhLT alpha 2 beta 1, rhOX40 Ligand, rhTNF-alpha, rhTRANCE, rhTRAIL, rh4-1BB, or rhAPRIL is observed.

Reconstitute at 0.5 mg/mL in sterile PBS.

Target Information

TNF-related weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily (TNFSF) of structurally related cytokines. Like most other members of this family, TWEAK is a cell surface-associated type II transmembrane protein although a smaller, biologically active form can also be generated by cleavage near the cell membrane. TWEAK has multiple biological activities, including stimulation of cell growth and angiogenesis, induction of inflammatory cytokines, in addition to stimulation of apoptosis. The TWEAK signal transduction pathway has not been well established but it appears to signal via TweakR/Fn14 in a manner similar to that described for other TNFSF members that bind receptors lacking death domains.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.