Thermo Fisher Scientific CD3 Monoclonal Antibody (MEM-57), FITC
인간 CD3 복합체의 외부 에피토프를 인식하는 Mouse IgG2a 단일클론 항체로, FITC 형광 표지되어 세포 분석(FACS)에 적합. 고순도 크로마토그래피 정제, 안정적 PBS/BSA 완충액 제공, 4°C 암소 보관.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 20 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-57 |
| Immunogen | Human thymocytes and T lymphocytes |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1071944 |
Additional Formats
- Unconjugated
- APC
- Biotin
- PE
- PerCP
- Custom conjugation available
Product Specific Information
This antibody reacts with an extracellular epitope on gamma-epsilon and delta-epsilon dimers of the human CD3 complex, which is part of the multisubunit T cell receptor complex (CD3/TCR) expressed on peripheral blood T lymphocytes and mature thymocytes.
Target Information
The CD3 subunit complex is essential for transducing antigen-recognition signals into T cell cytoplasm and regulating surface expression of the TCR complex. CD3 subunits (gamma, delta, epsilon, zeta) are structurally related members of the immunoglobulin superfamily encoded on chromosome 11. These subunits contain cytoplasmic tails with tyrosine-based motifs mediating signal transduction. CD3 is expressed on 68–82% of normal peripheral blood lymphocytes, 65–85% of thymocytes, and Purkinje cells in the cerebellum, but not on B or NK cells. Defects in CD3 genes are linked to CD3 immunodeficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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