Thermo Fisher Scientific CD10 Monoclonal Antibody (MEM-78), FITC
CD10 항원 인식용 마우스 단클론 항체로, FITC 형광 표지되어 유세포 분석에 적합합니다. 인간 시료 반응성이 있으며, CALLA 항원 검출에 활용됩니다. 액상 형태로 4°C 암소 보관하며, 면역세포 분석 연구용으로 사용됩니다.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 20 µL / 1×10⁶ cells
- Publications: View 3 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-78 |
| Immunogen | Pre-B cell line NALM-6 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1071095 |
Additional Formats
- Unconjugated (MA1-19086)
- APC (MA1-19733)
- PE (MA1-19627)
- PerCP (MA1-10064)
- Custom conjugation available
Product Specific Information
This antibody reacts with an extracellular epitope of the CD10 antigen (CALLA - Common Acute Lymphatic Leukemia Antigen), a 100 kDa type II integral membrane protein.
Target Information
CD10 (Common Acute Lymphocytic Leukemia Antigen, CALLA) is a cell surface enzyme with neutral metalloendopeptidase activity that inactivates various biologically active peptides.
It is expressed on:
- Lymphoblastic, Burkitt’s, and follicular germinal center lymphomas
- Immature B cells in adult bone marrow
- Cells from patients with chronic myelocytic leukemia (CML)
- Breast myoepithelial cells, bile canaliculi, fibroblasts
- Kidney and gut epithelial cell brush borders
CD10 cleaves peptides at the amino side of hydrophobic residues and inactivates peptide hormones such as glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.
It is a 100 kDa type II transmembrane glycoprotein encoded by a >45 kb gene with alternatively spliced 5′ UTRs that do not affect the coding region.
Diseases associated with CD10 dysfunction include spinocerebellar ataxia 43 and Charcot-Marie-Tooth disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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