Thermo Fisher Scientific Phospho-Glucocorticoid Receptor (Ser203) Polyclonal Antibody
Glucocorticoid Receptor (Ser203) 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal Antibody. Western blot과 Immunocytochemistry에 적합하며, Human 및 Mouse 시료에 반응. PBS/glycerol buffer에 보관, -20°C 저장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NR3C1 (Accession P04150), corresponding to amino acid residues around phosphorylated Ser203 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816023 |
Product Specific Information
This antibody detects endogenous levels of NR3C1 only when phosphorylated at Serine 203.
Target Information
Glucocorticoid Receptor (NR3C1) is a receptor for glucocorticoids that functions as both a transcription factor and a regulator of other transcription factors. It is typically located in the cytoplasm and translocates to the nucleus upon ligand binding.
The receptor is expressed in various heart tissues, including atria, ventricles, aorta, and septum.
Alternative splicing and promoter usage result in multiple transcript variants and isoforms.
Mutations in NR3C1 can cause glucocorticoid resistance.
The receptor interacts with chaperone proteins for ligand activation and binds steroids such as dexamethasone with nanomolar affinity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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