Thermo Fisher Scientific RyR2 Polyclonal Antibody
RyR2 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot, IHC(P), IHC(F), ICC/IF 등 다양한 응용에 적합합니다. 고순도 친화 크로마토그래피 정제, -20°C 보관, 연구용 전용 제품입니다.
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- PA5104444
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | – |
| Immunohistochemistry (Frozen) (IHC (F)) | – | View 1 publication |
| Immunocytochemistry (ICC/IF) | – | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RYR2 (Accession Q92736), corresponding to amino acid residues M2782–T2832 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853748 |
Product Specific Information
This antibody detects endogenous levels of total RYR2.
Target Information
Dihydropyridine receptor (DHPR) is a surface membrane protein critical for the excitation–contraction coupling of striated muscle. DHPR and the sarcoplasmic reticulum ryanodine receptor (RyR) are two key components of the intracellular junctions, where depolarization of the surface membrane is converted into the release of Ca²⁺ from internal stores. The alpha1-subunit of DHPR contains a cytoplasmic loop involved in interactions with RyR. Phosphorylation of the DHPR alpha1-subunit also plays a role in the functional interaction of DHPR and RyR. Mutation in DHPR alpha1 results in excitation–contraction uncoupling, leading to muscular dysgenesis and inactivity in developing skeletal muscles. Cells lacking RyR also lack excitation–contraction coupling and show a reduced Ca²⁺ current density.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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