Thermo Fisher Scientific HDAC8 Monoclonal Antibody (OTI1B2), TrueMAB
HDAC8 단백질을 표적으로 하는 Mouse IgG2b 단일클론 항체. Western blot에 최적화된 고감도 TrueMAB 포맷. 인간, 마우스, 랫트 반응성. 동결건조 형태로 제공되며, 재구성 후 1 mg/mL 농도 유지. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B2 |
| Immunogen | Human recombinant protein fragment (aa 1–243 of human HDAC8) produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For reconstitution, add 100 µL distilled water to achieve ~1 mg/mL antibody concentration.
- For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
DNA associates with histones and nuclear proteins to form chromatin. Chromatin remodeling, mediated by histone acetylation and deacetylation, regulates transcriptional activity. Acetylation of histone lysine residues increases accessibility to transcription factors, while deacetylation leads to transcriptional silencing.
HDAC8, a mammalian histone deacetylase isolated from human kidney, shares structural homology with other HDACs but differs in tissue distribution. It is nuclear-localized and plays roles in tissue development and cancer etiology.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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