Thermo Fisher Scientific SMAD4 Polyclonal Antibody
SMAD4 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC, ICC/IF, Flow Cytometry에 적합. Human, Mouse, Rat 반응성. Affinity chromatography로 정제된 액상 항체. 세포질 및 핵 내 SMAD4 검출에 사용. 연구용 전용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within human Smad4 aa 500–542 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2913214 |
Product Specific Information
- Positive Control: A549, Hela, SH-SY5Y, rat large intestine tissue, human placenta tissue, mouse small intestine tissue, HUVEC
- Subcellular Location: Cytoplasm, Nucleus
Target Information
Smad4 is encoded by the Smad4 gene located on chromosome 18 in humans. It is also known as Smad family member 4, Sma- and Mad-related protein 4, or Mothers against decapentaplegic (MAD) homolog 4.
Smad4 contains N-terminal MH1 (MAD homology 1) and C-terminal MH2 (MAD homology 2) globular domains that are involved in DNA binding and protein interactions, respectively.
Binding of the TGF-beta superfamily ligands, including Transforming Growth Factor-beta (TGF-β) and Bone Morphogenetic Protein (BMP), to their receptors induces phosphorylation of Smad1, 2, 3, 5, and 8 (R-Smads). These form heterotrimers with Smad4 (co-Smad) and translocate to the nucleus. Inhibitory Smads (Smad6, Smad7) interact with activated R-Smads to attenuate signaling.
Smad4 acts as a tumor suppressor by transcriptionally regulating target genes such as Cyclin D1 (downregulation) and collagen (upregulation), thereby inhibiting cell proliferation. Dephosphorylation regulates nuclear export and nucleocytoplasmic dynamics of Smads.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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