Thermo Fisher Scientific LOK Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:15,000

Immunoprecipitation (IP)

• Tested Dilution: 1–4 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt.

Target Information

Ubiquitin exists either covalently attached to another protein or free (unanchored). When covalently bound, it forms monoubiquitin or polyubiquitin chains linked via different Lys residues or the initiator Met.
Polyubiquitin chains have distinct roles depending on linkage type:

• Lys-6: DNA repair
• Lys-11: ERAD and cell-cycle regulation
• Lys-29: Lysosomal degradation
• Lys-33: Kinase modification
• Lys-48: Proteasome-mediated degradation
• Lys-63: Endocytosis, DNA damage response, NF-kappa-B activation
  Linear chains (Met-linked) are involved in cell signaling.
  Unanchored polyubiquitin also participates in kinase activation and signaling.

60S ribosomal protein L40 is a component of the 60S ribosomal subunit and is essential for translation of specific cellular and viral transcripts.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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