Thermo Fisher Scientific LOK Polyclonal Antibody
Thermo Fisher Scientific의 LOK Polyclonal Antibody는 인간 LOK 단백질의 C-말단 영역(900–968)을 인식하는 Rabbit IgG 항체입니다. Western blot과 Immunoprecipitation에 최적화되어 있으며, 항원 친화 크로마토그래피로 정제된 액상형 제품입니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:15,000
Immunoprecipitation (IP)
- Tested Dilution: 1–4 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 900 and the C-terminus (residue 968) of human Lymphocyte Oriented Kinase (Serine/Threonine Kinase 10) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
Ubiquitin exists either covalently attached to another protein or free (unanchored). When covalently bound, it forms monoubiquitin or polyubiquitin chains linked via different Lys residues or the initiator Met.
Polyubiquitin chains have distinct roles depending on linkage type:
- Lys-6: DNA repair
- Lys-11: ERAD and cell-cycle regulation
- Lys-29: Lysosomal degradation
- Lys-33: Kinase modification
- Lys-48: Proteasome-mediated degradation
- Lys-63: Endocytosis, DNA damage response, NF-kappa-B activation
Linear chains (Met-linked) are involved in cell signaling.
Unanchored polyubiquitin also participates in kinase activation and signaling.
60S ribosomal protein L40 is a component of the 60S ribosomal subunit and is essential for translation of specific cellular and viral transcripts.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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