Thermo Fisher Scientific NOXA Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.3–1 µg/mL

Product Specifications

Product Specific Information

This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.

Target Information

Apoptosis is related to many diseases and developmental processes. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA. A new p53 target gene, Noxa, was recently identified, encoding a protein belonging to the subfamily of BH3-only proapoptotic proteins.
Noxa and PUMA are both transcriptional targets of p53 and BH3-only proteins. X-ray irradiation increases p53-dependent Noxa mRNA and protein levels. When ectopically expressed, Noxa interacts with anti-apoptotic Bcl-2 family members, resulting in activation of caspase-9.
Noxa, like PUMA, localizes to mitochondria and induces apoptosis in response to p53. Increased levels of p53 and its target gene Noxa have been observed in impaired tumor development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.