Thermo Fisher Scientific NOXA Polyclonal Antibody
인간 NOXA 단백질을 인식하는 Thermo Fisher Scientific의 산양 다클론 항체입니다. Western blot에 최적화되어 있으며 0.3–1 µg/mL 농도로 사용 가능합니다. 합성 펩타이드 면역원으로 제작되었으며, 액상 형태로 -20°C에서 보관합니다. 연구용으로만 사용됩니다.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 0.3–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (TQLRRFGDKLNFRQK) corresponding to the internal amino acids of PMAIP1 (aa 27–42) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10986206 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.
Target Information
Apoptosis is related to many diseases and developmental processes. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA. A new p53 target gene, Noxa, was recently identified, encoding a protein belonging to the subfamily of BH3-only proapoptotic proteins.
Noxa and PUMA are both transcriptional targets of p53 and BH3-only proteins. X-ray irradiation increases p53-dependent Noxa mRNA and protein levels. When ectopically expressed, Noxa interacts with anti-apoptotic Bcl-2 family members, resulting in activation of caspase-9.
Noxa, like PUMA, localizes to mitochondria and induces apoptosis in response to p53. Increased levels of p53 and its target gene Noxa have been observed in impaired tumor development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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