Thermo Fisher Scientific SFRP4 Polyclonal Antibody
SFRP4 단백질을 인식하는 Thermo Fisher Scientific의 Goat Polyclonal Antibody로, WB와 IHC(P)에서 사용 가능. 인간 반응성, 고순도 정제, 안정적인 TBS 버퍼 제공. Wnt 신호 억제 연구 및 암·대사질환 연구에 적합.
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Thermo Fisher Scientific SFRP4 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–3 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–4 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (TNSSCQCPHILPHQD) corresponding to internal amino acids of SFRP4 (aa 239–254) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10983342 |
Product Specific Information
- Predicted to react with bovine, mouse, porcine, and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
Secreted Frizzled-Related Proteins (sFRPs) are a family of glycosylated Wnt antagonists characterized by a conserved cysteine-rich domain homologous to the extracellular domain of Frizzled proteins.
Unlike Frizzled receptors, sFRPs lack transmembrane and intracellular domains, functioning as soluble modulators of Wnt signaling by directly binding Wnt proteins and inhibiting receptor interaction and signaling.
sFRP-4 is broadly expressed in embryonic and adult tissues and acts as:
- Circulating antiangiogenic factor
- Proapoptotic factor
- Inhibitor of insulin secretion
- Suppressor of tumor growth and metastasis via Wnt pathway disruption
Downregulation or absence of circulating sFRP-4 correlates with progression of cancers such as ovarian, endometrial, prostate, and lung.
Upregulation is associated with impaired glucose metabolism in type 2 diabetes and suppression of keratinocyte hyperproliferation in psoriasis.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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