Thermo Fisher Scientific CRIM2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1-2 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A 15 amino acid synthetic peptide near the carboxy terminus of human CRIM2 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CRIM2,uniProtId:Q6ZWJ8-3,ncbiNodeId:9606,antigenRange:1568,antigenLength:1568,antigenImageFileName:PA5-34411_CRIM2_Q6ZWJ8-3_Rabbit.svg,antigenImageFileNamePDP:PA5-34411_CRIM2_Q6ZWJ8-3_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2551763

Product Specific Information

A suggested positive control is Jurkat cell lysate.

PA5-34411 can be used with blocking peptide PEP-1453.

Target Information

CRIM2, also known as Kielin/chordin-like protein (KCP), is a novel enhancer of BMP signaling. It binds to BMP7, a morphogen that is important for kidney development and part of the kidney`s physiological response to repair of acute kidney injury, enhancing its binding to its receptor. Because of this, CRIM2 has been suggested as a potential antifibrotic therapy in acute and chronic kidney injury. CRIM2 can also interact directly with either activin or TGF-Beta1, suppressing activin- and TGF-Beta1-dependent transcription.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.