Thermo Fisher Scientific Caspase 3 Polyclonal Antibody
Caspase-3 단백질을 인식하는 Rabbit Polyclonal Antibody로 인간 시료에 반응합니다. IHC 등 연구용으로 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 1 mg/mL 농도의 액상 형태이며, 냉장 또는 -20°C에서 장기 보관 가능합니다.
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Thermo Fisher Scientific Caspase 3 Polyclonal Antibody
Applications
- Immunohistochemistry (IHC)
Tested Dilution: 5 µg/mL
Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 17 amino acid synthetic peptide near the center of human Caspase-3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551765 |
Product Specific Information
PA5-34413 can be used with blocking peptide PEP-1455.
Target Information
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme.
This protein cleaves and activates caspases 6, 7, and 9, and is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer’s disease.
Alternative splicing of this gene results in two transcript variants that encode the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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