Thermo Fisher Scientific F13A1 Monoclonal Antibody (OTI4D2), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Product Specifications

Additional Formats

• Biotin
• Request custom conjugation

Product Specific Information

• For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
• For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of two A subunits (catalytic) and two B subunits (carrier). Platelet factor XIII consists of only two A subunits. Upon activation by thrombin and calcium, plasma factor XIII releases its B subunits and becomes the active enzyme factor XIIIa, identical to platelet-derived factor XIIIa. This enzyme catalyzes the formation of gamma-glutamyl-epsilon-lysine crosslinks between fibrin molecules, stabilizing the fibrin clot, and also crosslinks alpha-2-plasmin inhibitor or fibronectin to fibrin alpha chains.
Factor XIII deficiency includes:

• Type I deficiency: lack of both A and B subunits
• Type II deficiency: lack of A subunit only

These deficiencies can cause lifelong bleeding tendency, poor wound healing, and habitual abortion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.