Thermo Fisher Scientific MMP13 Monoclonal Antibody (OTI3A7), TrueMAB
인간 MMP13 단백질에 반응하는 Mouse IgG2a 단일클론 항체로, WB, IHC, ICC/IF에 사용 가능. 진정성 높은 TrueMAB 포맷으로 제작되어 높은 특이성과 재현성을 제공. 동결건조 형태로 공급되며, 재구성 후 1 mg/mL 농도로 실험에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3A7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 104–471 of human MMP13 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
MMP13 (collagenase 3) is involved in the degradation of extracellular matrix proteins such as fibrillar collagen, fibronectin, tenascin-C (TNC), and aggrecan (ACAN). It cleaves triple-helical collagens (types I, II, and III), showing highest activity with soluble type II collagen.
MMP13 also degrades collagen types IV, XIV, and X, contributing to wound healing, tissue remodeling, cartilage degradation, bone development, mineralization, and ossification.
It is essential for normal embryonic bone development and ossification. Mutations in MMP13 can cause spondyloepimetaphyseal dysplasia Missouri type, metaphyseal anadysplasia 1, and metaphyseal dysplasia Sphar type.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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