Thermo Fisher Scientific TG2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human Transglutaminase 2 (TG2). Validated for Western blot and immunoprecipitation. Supplied as liquid, unconjugated, 1 mg/mL concentration. Ideal for studying TGase-related cellular processes and neurodegenerative ...
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 625 to 675 of Human Transglutaminase 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
Transglutaminase (TGase) catalyzes protein crosslinking by forming ε-(γ-glutamyl) lysine isopeptide bonds and requires Ca²⁺ for activity.
In mammals, eight TGase isoenzymes are known. Tissue transglutaminase (tTGase or TGase 2) has four distinct domains: N-terminal β-sandwich, catalytic core, and two C-terminal β-barrel domains.
tTGase may play roles in cell death, proliferation, differentiation, and receptor-mediated endocytosis.
In Alzheimer’s disease, elevated tTGase activity is associated with polymerization of proteins such as Aβ peptide, β-amyloid precursor protein, and tau, contributing to neurofibrillary tangle formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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