Thermo Fisher Scientific BMP2 Monoclonal Antibody (1A11)

Applications

• ELISA (ELISA)
  • Tested Dilution: 1 ng/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
QAKHKQRKRL KSSCKRHPLY VDFSDVGWND WIVAPPGYHA FYCHGECPFP LADHLNSTNH AIVQTLVNSV NSKIPKACCV PTELSAISML YLDENEKVVL KNYQDMVVEG CGCR

Target Information

Bone Morphogenic Proteins (BMP) are members of the TGF-beta superfamily that affect bone and cartilage formation (Hogan 1996, Reddi 1998, Francis-West et al. 1999).
Mature BMPs are 30–38 kDa proteins that assume a TGF-beta-like cysteine knot configuration. Lovostatin increases bone formation by turning on the bmp-2 gene (Mundy et al. 1999).
BMPs stimulate the production of specific bone matrix proteins and alter stromal cell and osteoclast proliferation (Macias et al. 1999, Lecanda et al. 1997).
They may also play roles in development of viscera, cell proliferation, apoptosis, differentiation, and morphogenesis (Hogan 1996, Dale and Wardle 1999).
BMPs are responsible for normal dorsal/ventral patterning and bind to a type II receptor, which recruits a type I receptor unit, activating the Smad signaling pathway (Massague 1994, Derynck 1997, Attisano 1993).

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.