Thermo Fisher Scientific Phospho-Occludin (Thr382 ) Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:2,000
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Product Specifications

Product Specific Information

Antibody detects endogenous levels of Occludin only when phosphorylated at Thr382 (mouse).

Target Information

Occludin is a 65 kDa protein that can exist in a variety of phosphorylated forms, ranging up to approximately 82 kDa. It is involved in regulating both the localization and the function of occludin. Polyunsaturated fatty acids are known to up-regulate occludin expression, increasing transendothelial cell resistance and reducing cellular permeability to large molecules. Expression levels vary by tissue, being high and continuous in brain tissue, while lower and discontinuous in non-neural tissues. Structural features of occludin are conserved across species. Under-expression of tight junction proteins, including occludin, is associated with increased permeability of tumor endothelial tight junctions, contributing to brain tumor edemas.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.