Thermo Fisher Scientific Human CYR61 Recombinant Protein, PeproTech
인간 CYR61 재조합 단백질로, 혈관 생성 및 세포 부착 연구에 활용 가능. E. coli 발현 시스템에서 생산되며 ≥95% 순도. 39.4 kDa 크기의 단백질로 murine 3T3 세포 증식 활성 확인됨. 연구용으로만 사용.
- 카탈로그번호
- 120-25-01M
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Applications
Functional Assay (Functional)
- Assay-dependent
In vitro Assay (IV)
- Refer to publications (5 available)
Miscellaneous PubMed (Misc)
- Refer to publications (3 available)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Published species | Chicken, Human, Mouse, Rat |
| Expression System | E. coli |
| Amino acid sequence | TCPAACHCPL EAPKCAPGVG LVRDGCGCCK VCAKQLNEDC SKTQPCDHTK GLECNFGASS TALKGICRAQ SEGRPCEYNS RIYQNGESFQ PNCKHQCTCI DGAVGCIPLC PQELSLPNLG CPNPRLVKVT GQCCEEWVCD EDSIKDPMED QDGLLGKELG FDASEVELTR NNELIAVGKG SSLKRLPVFG MEPRILYNPL QGQKCIVQTT SWSQCSKTCG TGISTRVTND NPECRLVKET RICEVRPCGQ PVYSSLKKGK KCSKTKKSPE PVRFTYAGCL SVKKYRPKYC GSCVDGRCCT PQLTRTVKMR FRCEDGETFS KNVMMIQSCK CNYNCPHANE AAFPFYRLFN DIHKFRD |
| Molecular weight | 39.4 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 95% by SDS-PAGE gel and HPLC analyses |
| Endotoxin concentration | <1 EU/µg |
| Activity | Dose-dependent stimulation of murine 3T3 cell proliferation (ED50: 2.0–3.0 µg/ml) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage conditions | -20°C |
Product Specific Information
- Catalog No. 120-25-1MG is supplied as 2 × 500 µg (120-25-500UG).
- Recombinant Human CYR61 is a 39.5 kDa protein containing 357 amino acids.
- Composed of four structural domains:
- IGF Binding Protein (IGFBP) domain
- von Willebrand Factor C (VWFC) domain
- Thrombospondin type-I (TSP type-1) domain
- C-terminal Cysteine Knot-like (CTCK) domain
- Shipped at ambient temperature.
- Refer to the lot-specific Certificate of Analysis for storage, handling, and reconstitution details.
Target Information
CYR61 is a secreted heparin-binding protein encoded by a growth factor-inducible gene. It associates with the extracellular matrix and connective tissue and belongs to the CCN family of angiogenic regulators, including CTGF and Fisp12. CYR61 binds to integrin αvβ3, promoting cell adhesion, migration, and DNA synthesis in human vascular endothelial cells. Expression increases during vessel growth, wound healing, and chondrocyte differentiation. It is also detected in various tumors, functioning as a marker of tumor progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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