Thermo Fisher Scientific NR2E1 Monoclonal Antibody (1C4)
NR2E1(TLX) 단백질을 인식하는 Mouse IgG2a 단클론 항체로, Human 및 Mouse 시료에 반응. Western blot과 ELISA에 사용 가능. GST 태그 결합 재조합 단백질을 면역원으로 제작. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1C4 |
| Immunogen | NR2E1 (NP_003260, 249–342 a.a) partial recombinant protein with GST tag (MW of GST = 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
NGDNTDSQKL NKIISEIQAL QEVVARFRQL RLDATEFACL KCIVTFKAVP THSGSELRSF RNAAAIAALQ DEAQLTLNSY IHTRYPTQPC RFGK
Target Information
Nuclear receptor TLX, a NR2 hepatocyte NF4-like receptor, is involved in anterior brain differentiation, retinal development, and vision. TLX targets genes such as RAR beta2 and Pax2 during retinal development.
Homozygous TLX mutant mice exhibit reduced forebrain development and increased aggression. Deletion of TLX locus leads to cerebral hypoplasia, blindness, and extreme aggression (fierce phenotype).
TLX expression has been documented in mouse brain and eye, and ESTs have been isolated from normal human brain libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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