Thermo Fisher Scientific PIGR Monoclonal Antibody (1E2B12)

Applications and Tested Dilutions

Product Specifications

Target Information

Polymeric IgA and IgM are produced and secreted by B cells in the lamina propria, located beneath the mucosal lining of polarized epithelial cells. Polymeric immunoglobulin receptors (pIgRs) are expressed on the basolateral surface of glandular epithelia and mediate transcellular transport of secretory immunoglobulin polymers across the epithelium.

pIgR associates with secreted dimeric IgA and IgM molecules. During transcellular transport, pIgR undergoes proteolytic cleavage to generate a fragment called the secretory component (SC), also known as the polymeric immunoglobulin receptor or poly-IG receptor. When immunoglobulin polymers associate with SC, they become resistant to enzymatic degradation during transcytosis.

SC and pIgR are crucial for proper mucosal immunity, serving as molecular chaperones that protect polymeric Igs and enable their transport into body fluids. The human SC (pIgR) gene maps to chromosome 1q31–q41 and encodes a 764 amino acid protein. The receptor contains five units homologous to immunoglobulin variable (V) regions and a transmembrane region sharing similar homology.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.