Thermo Fisher Scientific MTF2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Predicted reactivity: Mouse (98%), Rat (96%), Chicken (90%).

Target Information

Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at Lys-36 (H3K36me3) and recruits the PRC2 complex.
Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhanced PRC2 H3K27me3 methylation activity.
Regulates transcriptional networks during embryonic stem cell self-renewal and differentiation.
Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and to target genes in undifferentiated ES cells.
Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex.
In some conditions, may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing PRC2 catalytic activity locally.
Binds to the metal-regulating-element (MRE) of the MT1A gene promoter.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.