Thermo Fisher Scientific MTF2 Polyclonal Antibody
MTF2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, IHC(P) 및 ICC/IF에 사용 가능. Human과 Mouse에 반응하며, 항원 친화 크로마토그래피로 정제됨. PBS buffer(20% glycerol) 내 액상 형태로 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 401–593 of MTF2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| RRID | AB_2553241 |
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Predicted reactivity: Mouse (95%), Rat (95%), Chicken (92%), Bovine (100%).
Target Information
Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at Lys-36 (H3K36me3) and recruits the PRC2 complex.
Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhanced PRC2 H3K27me3 methylation activity.
Regulates transcriptional networks during embryonic stem cell self-renewal and differentiation.
Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and to target genes in undifferentiated ES cells.
Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex.
In some conditions, may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing PRC2 catalytic activity locally.
Binds to the metal-regulating-element (MRE) of the MT1A gene promoter.
주의사항
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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