Thermo Fisher Scientific Human LYN A, GST Tag Recombinant Protein
인간 LYN A 단백질을 GST 태그로 발현한 정제된 재조합 단백질로, 키나아제 활성 및 결합 분석에 적합합니다. Baculovirus 시스템에서 발현되며, 질병 관련 연구와 약물 스크리닝에 활용 가능합니다. -80°C에서 보관하며, 동결·해동을 피해야 합니다.
- 카탈로그번호
- PV6448
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Human LYN A, GST Tag Recombinant Protein
Applications
- Kinase Assay (KA)
Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | Baculovirus |
| Amino Acid Sequence | Full length |
| Tag | GST-tag |
| Molecular Weight | 81 kDa |
| Class | Recombinant |
| Type | Protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Purified |
| Storage Buffer | 50nM Tris HCl, pH 7.5, with 25% glycerol, 0.1mM PMSF, 0.25mM DTT, 150mM NaCl, 0.1mM EGTA, 0.1mM EDTA |
| Contains | No preservative |
| Storage Conditions | -80°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Dry ice |
Product Specific Information
- For maximum recovery, please spin prior to use.
- Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use materials in original packaging until exhausted.
- For larger sizes, prepare aliquots to reduce freeze/thaw cycles; aliquots below 20 µL are not recommended.
- Never store a kinase diluted.
- Properly stored at -80°C, product is guaranteed for 6 months from date of purchase.
Key Features:
- Increase disease relevance by interrogating a purified and active full-length LYN A reagent
- Uncover novel compounds or hits specific to the full-length form
- Advance research using full-length protein and validated assays
Assay Platforms
- LanthaScreen™ TR-FRET Kinase Activity Assay
- LanthaScreen™ Eu Kinase Binding Assay
- Z`-LYTE™ Kinase Activity Assay
Protein Form: Recombinant, Full Length
Gene Accession Number: NP_002341.1
Target Information
LYN (v-yes-1 Yamaguchi sarcoma viral related oncogene homolog) is a SRC family kinase expressed predominantly in hematopoietic, neural, liver, and adipose tissue. It is a protein-coding gene associated with diseases such as alexia and chorea-acanthocytosis. Activation of LYN has been shown to lead to imatinib resistance in CML patients.
LYN B and the slightly shorter LYN A are the two isoforms of LYN. An important paralog of Lyn Isoform A is FRK.
The full-length LYN A protein enables researchers to study mechanisms underlying disease.
Diseases associated with LYN include Sarcoma and Myeloid Leukemia.
Related pathways include:
- Signaling by Erythropoietin
- Regulation of actin dynamics for phagocytic cup formation
Gene Ontology (GO) annotations:
- Transferase activity, transferring phosphorus-containing groups
- Protein tyrosine kinase activity
An important paralog of Lyn Isoform A is HCK.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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