Thermo Fisher Scientific Human LYN A, GST Tag Recombinant Protein

Thermo Fisher Scientific Human LYN A, GST Tag Recombinant Protein

Applications

• Kinase Assay (KA)

Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• For maximum recovery, please spin prior to use.
• Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use materials in original packaging until exhausted.
• For larger sizes, prepare aliquots to reduce freeze/thaw cycles; aliquots below 20 µL are not recommended.
• Never store a kinase diluted.
• Properly stored at -80°C, product is guaranteed for 6 months from date of purchase.

Key Features:

• Increase disease relevance by interrogating a purified and active full-length LYN A reagent
• Uncover novel compounds or hits specific to the full-length form
• Advance research using full-length protein and validated assays

Assay Platforms

• LanthaScreen™ TR-FRET Kinase Activity Assay
• LanthaScreen™ Eu Kinase Binding Assay
• Z`-LYTE™ Kinase Activity Assay

Protein Form: Recombinant, Full Length
Gene Accession Number: NP_002341.1

Target Information

LYN (v-yes-1 Yamaguchi sarcoma viral related oncogene homolog) is a SRC family kinase expressed predominantly in hematopoietic, neural, liver, and adipose tissue. It is a protein-coding gene associated with diseases such as alexia and chorea-acanthocytosis. Activation of LYN has been shown to lead to imatinib resistance in CML patients.
LYN B and the slightly shorter LYN A are the two isoforms of LYN. An important paralog of Lyn Isoform A is FRK.
The full-length LYN A protein enables researchers to study mechanisms underlying disease.
Diseases associated with LYN include Sarcoma and Myeloid Leukemia.
Related pathways include:

• Signaling by Erythropoietin
• Regulation of actin dynamics for phagocytic cup formation

Gene Ontology (GO) annotations:

• Transferase activity, transferring phosphorus-containing groups
• Protein tyrosine kinase activity

An important paralog of Lyn Isoform A is HCK.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.