Thermo Fisher Scientific Phospho-KSR1 (Ser392) Polyclonal Antibody
Phospho-KSR1 (Ser392) 특이적 Rabbit Polyclonal Antibody로 Western blot에 적합. Human, Mouse, Rat 등 다양한 종에 반응. 항원 친화 크로마토그래피로 정제된 액상 형태. 연구용으로만 사용 가능.
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Thermo Fisher Scientific Phospho-KSR1 (Ser392) Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution
- 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pSer392 of mouse KSR1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10981116 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
KSR1 is part of a multiprotein signaling complex that promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Independently of its kinase activity, it acts as a MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF. Upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, KSR1 dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). It promotes activation of MAPK1 and/or MAPK3 in response to EGF and cAMP. Its kinase activity is uncertain; although some activity has been detected in vitro, its physiological relevance remains unclear. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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