Thermo Fisher Scientific CD79a Monoclonal Antibody (HM47), APC-eFluor 780, eBioscience
CD79a 단백질을 인식하는 HM47 클론의 단클론 항체로, APC-eFluor 780 형광체가 결합되어 있습니다. Flow cytometry용으로 최적화되어 있으며, 다양한 종에 반응합니다. B세포 마커로 신뢰성이 높고, 광산화에 민감하므로 암실 보관이 필요합니다.
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Thermo Fisher Scientific CD79a Monoclonal Antibody (HM47), APC-eFluor 780, eBioscience
Applications
- Flow Cytometry (intracellular staining)
Tested Dilution: 5 µL (0.06 µg)/test
Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Non-human primate, Pig, Rhesus monkey, Rat, Baboon, Bovine, Dog, Chicken, Chimpanzee, Horse, Guinea pig, Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), APC-eFluor™ 780, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HM47 |
| Conjugate | APC-eFluor™ 780 |
| Additional Formats | PE, PerCP-Cyanine5.5, Request custom conjugation |
| Excitation/Emission Max | 756/785 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2573968 |
Product Specific Information
The monoclonal antibody HM47 recognizes the cytoplasmic domain of CD79a (mb-1), a 47 kDa membrane glycoprotein that associates with CD79b to form the heterodimeric B cell receptor (BCR). This receptor mediates B cell signaling, leading to activation, apoptosis, or anergy. CD79a is expressed from pre-B cells to plasma cells and is a reliable marker for B cells, including neoplasms.
- Epitope: Typically amino acids 208–222 (human)
- Reactivity: Human, mouse, rat, dog, primates (rhesus, chimpanzee, macaque, baboon), pig, guinea pig, horse, cow, chicken
- Applications Reported: Intracellular staining followed by flow cytometric analysis
- Applications Tested: Pre-titrated and validated for 5 µL (0.06 µg)/test in 100 µL total volume (10⁵–10⁸ cells/test)
- Fluorochrome Info: APC-eFluor 780 (Excitation: 633–647 nm; Emission: 780 nm; Laser: Red)
- Light Sensitivity: Protect from light (photo-induced oxidation)
- Fixation: Compatible with IC Fixation Buffer (Product #00-8222) or 1-step Fix/Lyse Solution (Product #00-5333); store up to 3 days at 4°C in dark
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
CD79a forms a disulphide-linked heterodimer with CD79b (B29) and is a critical component of the B-cell antigen receptor complex. It appears at the pre-B cell stage and persists until the plasma cell stage as an intracellular component. CD79a is expressed in most precursor B-cell leukemias, B-cell lines, lymphomas, and some myelomas, but absent in myeloid or T-cell lines.
Associated Diseases: Agammaglobulinemia 3, Agammaglobulinemia (Non-Bruton type)
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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