Thermo Fisher Scientific USP13 Polyclonal Antibody

Applications

• Western Blot (WB): Assay-dependent

Product Specifications

Target Information

Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD).
Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilization of the PIK3C3/VPS34-containing complexes.
Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting a regulatory system by which these complexes control p53/TP53 levels via USP10 and USP13.
Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating ERAD. Also regulates ERAD through deubiquitination of UBL4A, a component of the BAG6/BAT3 complex.
Mediates stabilization of SIAH2 independently of deubiquitinase activity by binding ubiquitinated SIAH2 and impairing its autoubiquitination. Has weak deubiquitinase activity in vitro and preferentially cleaves Lys-63-linked polyubiquitin chains.
Unlike USP5, it cannot mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro; further experiments required to confirm.
[UniProt]

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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