Thermo Fisher Scientific IL-22 Receptor alpha Polyclonal Antibody
IL-22 수용체 알파에 특이적인 Rabbit Polyclonal 항체로, 인간, 마우스, 랫트에 반응합니다. WB, IHC, ICC/IF에 사용 가능하며, 친화 크로마토그래피로 정제되었습니다. 세포막 위치 단백질 검출에 적합하며 연구용으로만 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunocytochemistry (ICC/IF) | 1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within human IL-22RA1 aa 1–50/574 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3093527 |
Product Specific Information
- Positive controls: 293T cell lysate, HepG2 cell lysate, K562 cell lysate, HeLa, SiHa, mouse kidney tissue, rat pancreas tissue
- Predicted band size: 63 kDa
- Subcellular Location: Membrane
Target Information
A novel cytokine, designated IL-TIF (IL-10 related T cell-derived inducible factor) and IL-22, was recently identified.
The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family.
IL-22R forms a complex with IL-10 receptor beta chain and mediates IL-22 signaling via the JAK-STAT pathway.
IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10.
A soluble form of IL-22 receptor, termed IL-22 binding protein (IL-22BP or IL-22RA2), prevents IL-22 binding to the functional receptor complex and neutralizes its activity.
LPS induces IL-22 expression, indicating its role in inflammatory response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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