Thermo Fisher Scientific PLP1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

PA3-151 detects proteolipid protein in mouse samples.
It has been successfully used in Western blot and immunocytochemistry procedures.
By Western blot, this antibody detects ~23–26 kDa proteins representing the proteolipid protein and the splice variant DM20 in adult mouse brain samples.
The PA3-151 immunogen is a synthetic peptide corresponding to the C-terminal residues K(269) L M G R G T K(276) of PLP.

Target Information

PLP1 is a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system.
It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival.
Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2.
Alternatively spliced transcript variants encoding distinct isoforms or having different 5′ UTRs have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.