Thermo Fisher Scientific Phospho-CDK6 (Tyr24) Polyclonal Antibody
CDK6 Tyr24 인산화 부위를 인식하는 Rabbit Polyclonal Antibody로, Western blot, IHC, ICC/IF에 적합. 인간, 마우스, 랫트 반응성. 액상 형태, 1 mg/mL 농도, PBS/glycerol buffer에 보관. 세포주 기반 양성 대조군 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:100–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 24 (G-A-Y(p)-G-K) derived from Human CDK6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554127 |
Product Specific Information
- Suggested positive control for Western blot: 293 cells
- Suggested positive control for IHC: human colon carcinoma
- Suggested positive control for ICC/IF: HeLa cells
Target Information
CDK6 functions as a cell-cycle initiator protein, coexpressed and copurified with Cyclin D1. They are critical regulators of cell cycle progression. The prototype member of this family, p34cdc2, and related protein cdk2, act late in the cycle, while cdk4 and cdk6 are involved in G1 to S progression. CDK6 is essential for cell proliferation within the dentate gyrus of the hippocampus and the cuventricular zone of the lateral ventricles. Mutations in the gene result in microcephaly 12, primary, autosomal recessive (MCPH12).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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