Thermo Fisher Scientific GRPR Polyclonal Antibody
GRPR 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P)에서 사용 가능. 인간 및 다양한 종에 반응하며, 항원 친화 크로마토그래피로 정제됨. 액상 형태로 제공되며 4°C 또는 -20°C에서 보관. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 4 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bat, Dog, Horse, Human, Non-human primate, Pig, Rabbit |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 18 amino acid peptide from 2nd extracellular domain of human GRPR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551203 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Gorilla, Gibbon, Monkey, Marmoset, Elephant, Panda, Dog, Bat, Horse, Rabbit, Pig (100%)
Bovine (94%)
Target Information
Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. It acts as a potent mitogen for neoplastic tissues.
The effects of GRP are mediated through the gastrin-releasing peptide receptor (GRPR), a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway.
GRPR is aberrantly expressed in various cancers such as lung, colon, and prostate.
A case of autism and multiple exostoses was associated with a balanced translocation between chromosome 8 and a chromosome X breakpoint within the GRPR gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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