Thermo Fisher Scientific GRPR Polyclonal Antibody
GRPR 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. IHC 및 ICC/IF에 사용 가능하며, 다양한 종에 반응. 항원 친화 크로마토그래피로 정제된 액상 형태로 제공. 연구용으로만 사용.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 15–20 µg/mL
Immunocytochemistry (ICC/IF)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bat, Bovine, Dog, Hamster, Human, Mouse, Non-human primate, Pig, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 17 amino acid peptide from 3rd cytoplasmic domain of human GRPR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551204 |
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Bovine, Dog, Bat, Pig (100%).
Target Information
Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. It is a potent mitogen for neoplastic tissues.
The effects of GRP are mediated through the gastrin-releasing peptide receptor (GRPR), a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway.
The receptor is aberrantly expressed in numerous cancers such as lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the GRPR gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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