Thermo Fisher Scientific mGluR7 Polyclonal Antibody
mGluR7 단백질을 인식하는 Rabbit Polyclonal 항체로, Western Blot 및 IHC(P)에서 검증됨. 다양한 종에 반응하며 항원 친화 크로마토그래피로 정제됨. 1 mg/mL 농도의 액상 형태로 제공되며, 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 7 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Dog, Horse, Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 20 amino acid peptide from N-terminal extracellular domain of human GRM7 / MGLUR7 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551197 |
Target Information
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions.
Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors divided into three groups based on sequence homology, signal transduction mechanisms, and pharmacologic properties:
- Group I: GRM1, GRM5 — activate phospholipase C
- Group II: GRM2, GRM3
- Group III: GRM4, GRM6, GRM7, GRM8
Groups II and III are linked to inhibition of the cyclic AMP cascade but differ in agonist selectivities. Multiple transcript variants encoding different isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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