Thermo Fisher Scientific Phospho-VEGF Receptor 2 (Tyr1059) Polyclonal Antibody
VEGFR2의 Tyr1059 인산화 형태를 특이적으로 인식하는 rabbit polyclonal antibody. Western blot 및 Immunocytochemistry에 적합하며, 내인성 VEGFR2의 인산화 상태 분석에 유용. 액상 형태로 -20°C 보관, 1 mg/mL 농도.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human KDR (Accession P35968), corresponding to amino acid residues around phosphorylated Tyr1059 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816354 |
Product Specific Information
This antibody detects endogenous levels of VEGFR2 only when phosphorylated at Tyrosine 1059.
Target Information
KDR (FLK1, VEGFR2) is a type III receptor tyrosine kinase that binds vascular endothelial growth factor (VEGF) with high affinity. It is expressed early in development by endothelial cell precursors. FLK1 (VEGF Receptor 2) encodes one of the two receptors for VEGF, known as the kinase insert domain receptor. The signaling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin αVβ3, and T-cell protein tyrosine phosphatase. Mutations in FLK1 (VEGF Receptor 2) are implicated in infantile capillary hemangiomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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