Thermo Fisher Scientific ACY1 Monoclonal Antibody (OTI1D4), TrueMAB

Thermo Fisher Scientific ACY1 Monoclonal Antibody (OTI1D4), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

ACY1 encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes hydrolysis of acylated L-amino acids to L-amino acids and acyl groups. It is involved in catabolism and salvage of acylated amino acids.
The gene is located on chromosome 3p21.1, a region associated with small-cell lung cancer (SCLC), where its expression is often reduced or undetectable.
Mutations in ACY1 cause aminoacylase-1 deficiency, a metabolic disorder characterized by CNS defects and increased urinary excretion of N-acetylated amino acids.
Alternative splicing results in multiple transcript variants, and read-through transcription occurs with the upstream ABHD14A gene. A related pseudogene exists on chromosome 18.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

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