Thermo Fisher Scientific ACY1 Monoclonal Antibody (OTI2D3), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:200–1:500

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:150

Flow Cytometry (Flow)

• Tested Dilution: 1:100

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

ACY1 encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group. It is involved in the catabolism and salvage of acylated amino acids.
This gene is located on chromosome 3p21.1, a region associated with small-cell lung cancer (SCLC), where expression is often reduced or undetectable.
Mutations in ACY1 cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids.
Alternative splicing results in multiple transcript variants, and read-through transcription occurs with the upstream ABHD14A gene. A pseudogene is present on chromosome 18.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.