Thermo Fisher Scientific SURF1 Polyclonal Antibody
SURF1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P) 응용에 적합합니다. Human, Mouse, Rat 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 1 mg/mL 농도의 액상 형태로 제공되며, 4°C 또는 -20°C에서 보관 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 150–200 of human SURF-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C for short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2553411 |
Product Specific Information
- Detects endogenous SURF1 protein at ~33 kDa.
- Purity >95% by SDS-PAGE.
Target Information
The SURF-1 protein plays a crucial role in the assembly of complex IV (CIV or COX) of the mitochondrial respiratory chain. It is localized in the inner mitochondrial membrane. Mutations in the SURF-1 gene are associated with cytochrome c oxidase complex IV deficiency, leading to Leigh syndrome — a severe neurological disorder characterized by necrotic lesions in subcortical brain regions. SURF-1 mutations also correlate with embryonic lethality, early-onset mortality, and muscle and motor performance deficits. Morphological abnormalities in heart, brain, and skeletal muscle are frequently observed due to SURF-1 dysfunction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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