Thermo Fisher Scientific CD20 (MS4A1) Monoclonal Antibody (OTI11F7), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: Assay-Dependent

Product Specifications

Additional Formats

• Biotin
• Request custom conjugation

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

CD20 is a non-glycosylated surface phosphoprotein (33–37 kDa) expressed on mature and most malignant B cells, a subset of T lymphocytes, and follicular dendritic cells.
It regulates calcium conductance, cell cycle progression, and B-cell proliferation.
CD20 is associated with lipid rafts and interacts dynamically with the B-cell receptor (BCR) during activation.
Because CD20 remains on the cell surface and is not shed or internalized after antibody binding, it is an ideal target for antibody-mediated depletion of B cells.
Diseases associated with CD20 dysfunction include MS4A1-related common variable immune deficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.