Thermo Fisher Scientific MCU Monoclonal Antibody (CL3576)
Thermo Fisher Scientific의 MCU Monoclonal Antibody(CL3576)는 인간 MCU 단백질을 인식하는 Mouse IgG1 항체입니다. WB 및 ICC/IF에 적합하며, 높은 특이성과 재현성을 제공합니다. 연구용으로만 사용되며, Protein A로 정제된 액상 형태로 제공됩니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | View 1 publication |
| Immunocytochemistry (ICC/IF) | 2–10 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CL3576 |
| Immunogen | Recombinant Human MCU |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.00 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664126 |
Product Specific Information
Immunogen sequence:
TRQEYVYPEAR DRQYLLFFHK GAKKSRFDLE KYNQLKDAIA QAEMDLKRLR DPLQVHLPLR QIGE
Binds to an epitope located within the peptide sequence RDRQYLLFFH as determined by overlapping synthetic peptides.
Highest antigen sequence identity to the following orthologs: mouse 100%, rat 100%.
Target Information
Mitochondrial inner membrane calcium uniporter (MCU) mediates calcium uptake into mitochondria. It forms the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex).
Activity is regulated by MICU1 and MICU2 — down-regulated at low Ca²⁺ levels and up-regulated at higher levels.
MCU plays crucial roles in cellular physiology, bioenergetics, cytoplasmic calcium signaling, and cell death regulation.
It is involved in:
- Buffering systolic calcium rises in cardiomyocytes
- Mitochondrial calcium loading during acute stress ("fight-or-flight" response)
- Mitochondrial permeability transition in ischemia-reperfusion injury
- Glucose-dependent insulin secretion in pancreatic beta-cells
- Muscle size regulation in adults
- Synaptic vesicle endocytosis kinetics
- Antigen processing and presentation
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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