Thermo Fisher Scientific Clusterin/Apolipoprotein J (APO-J) Monoclonal Antibody (CLU/4727)
Clusterin/Apolipoprotein J 단백질을 인식하는 Mouse monoclonal antibody. Western blot, IHC 등 다양한 응용에 적합. Recombinant fragment (aa150-300)을 면역원으로 제작. 단백질 응집 방지 및 세포 보호 기능 연구에 활용 가능.
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- 1191-MSM7-P1ABX
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2–4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2c, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CLU/4727 |
| Immunogen | Recombinant fragment (around aa150–300) of human CLU protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Isoform 1 functions as an extracellular chaperone that prevents aggregation of nonnative proteins and stress-induced aggregation of plasma proteins. It inhibits amyloid fibril formation by several aggregation-prone proteins and maintains unfolded proteins for refolding by other chaperones. Clusterin does not refold proteins independently but mediates their internalization and degradation through lysosomal or proteasomal pathways. Secreted isoforms protect cells from apoptosis and complement-mediated cytolysis, while intracellular and nuclear isoforms regulate ubiquitination, NF-κB activity, and apoptosis. Mitochondrial isoforms suppress BAX-dependent cytochrome c release, contributing to cell survival and proliferation regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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