Thermo Fisher Scientific MERTK Polyclonal Antibody
Thermo Fisher Scientific의 MERTK Polyclonal Antibody는 인간, 마우스, 랫트에서 반응하며 Western Blot 및 Immunocytochemistry에 적합합니다. 합성 펩타이드 기반 면역원으로 제조된 rabbit IgG 항체이며, 액상 형태로 1 mg/mL 농도, -20°C 보관 조건을 권장합니다. 연구용 전용 제품입니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MERTK (Accession Q12866), corresponding to amino acid residues R727–Y777 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851458 |
Product Specific Information
Antibody detects endogenous levels of total MERTK.
Target Information
MERTK (cMER) is a tyrosine kinase proto-oncogene involved in the retinal pigment epithelium (RPE) phagocytosis pathway, which is implicated in human retinal disease. It regulates various physiological processes including:
- Cell survival, migration, and differentiation
- Phagocytosis of apoptotic cells (efferocytosis)
- Autophosphorylation upon ligand binding, providing docking sites for downstream signaling molecules
Following activation, MERTK interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2, or RAC1. MERTK signaling contributes to macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization, and engulfment. In RPE, it regulates rod outer segment fragment phagocytosis and inhibits Toll-like receptor (TLR)-mediated innate immune responses by activating STAT1, which induces SOCS1 and SOCS3 production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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