Thermo Fisher Scientific G-CSF Monoclonal Antibody (S1390)

Thermo Fisher Scientific G-CSF Monoclonal Antibody (S1390)

Applications

• Western Blot (WB): Assay-dependent
• ELISA: Assay-dependent

Product Specifications

Product Specific Information

MA1-26098 detects G-CSF Receptor from human samples.

Target Information

G-CSF (Granulocyte colony stimulating factor) is a naturally occurring cytokine that stimulates the production and antibacterial function of neutrophils and monocytes. Human G-CSF is an 18.8 kDa protein containing 175 amino acid residues, and a soluble isoform of the G-CSF receptor has been described.
This pleiotropic cytokine is produced by activated monocytes, macrophages, endothelial cells, fibroblasts, astrocytes, osteoblasts, and bone marrow cells. It influences proliferation, differentiation, and activation of hematopoietic cells and is expressed by various transformed cells such as carcinoma and myeloblastic leukemia cells.
G-CSF is encoded by two distinct DNA sequences, resulting in a full-size, high-activity and a shorter, low-activity isoform. Highly conserved among species, G-CSF interacts with its receptor on hematopoietic progenitors, neutrophilic granulocytes, and certain carcinoma cell lines.
Clinically, G-CSF is used for treatment of neonatal infections, acute myocardial infarction, neutropenia, severe infections and sepsis, chronic autoimmune neutropenia, acute myeloid leukemias, Sweet’s syndrome, and AIDS. It is also a marker for carcinomas such as bladder cancer, and dysfunction of the protein has been linked to Kostmann Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.