Thermo Fisher Scientific Phospho-c-Raf (Tyr341) Polyclonal Antibody
Phospho-c-Raf (Tyr341) 폴리클로날 항체로 인간 세포 반응성. ICC/IF 및 Dot blot에 사용 가능. Rabbit IgG 기반, 0.3 mg/mL 농도. Protein A 및 항원 친화 크로마토그래피로 정제. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1:100 |
| Dot blot (DB) | 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y341 of human RAF1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11009495 |
Product Specific Information
This antibody is predicted to react with bovine, chicken, mouse, and rat based on sequence homology.
Target Information
Raf-1 (c-Raf) is a MAP kinase kinase kinase (MAP3K) functioning downstream of the Ras family of membrane-associated GTPases. Once activated, Raf-1 phosphorylates and activates the dual specificity protein kinases MEK1 and MEK2, which in turn activate ERK1 and ERK2. Activated ERKs are key regulators of gene expression, cell division, apoptosis, differentiation, and migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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