Thermo Fisher Scientific Phospho-c-Abl (Tyr185) Polyclonal Antibody
Human c-Abl (Tyr185) 인산화 부위를 인식하는 Rabbit Polyclonal Antibody로, ICC/IF 및 Dot blot에 사용 가능. KLH 결합 합성 인산화 펩타이드로 면역화. Protein A 및 항원 친화 크로마토그래피로 정제. PBS buffer에 보관하며 장기 저장 시 -20°C 권장.
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Thermo Fisher Scientific Phospho-c-Abl (Tyr185) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1:10–1:50 |
| Dot blot (DB) | 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y185 of human ABL1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10980512 |
Product Specific Information
This antibody is predicted to react with mouse based on sequence homology.
Target Information
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase involved in cell differentiation, division, adhesion, and stress response.
- The c-Abl protein activity is negatively regulated by its SH3 domain; deletion of this domain converts c-Abl into an oncogene.
- CDC2-mediated phosphorylation regulates the DNA-binding activity of ABL1, suggesting a role in the cell cycle.
- In chronic myelogenous leukemia and some acute lymphoblastic leukemias, a (9;22) translocation produces the Philadelphia chromosome, fusing c-Abl from chromosome 9 with the Bcr gene on chromosome 22.
- c-Abl was first identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV).
- It may regulate DNA repair by triggering apoptosis when DNA damage is irreparable.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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