Thermo Fisher Scientific Phospho-c-Abl (Tyr185) Polyclonal Antibody

Thermo Fisher Scientific Phospho-c-Abl (Tyr185) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody is predicted to react with mouse based on sequence homology.

Target Information

The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase involved in cell differentiation, division, adhesion, and stress response.

• The c-Abl protein activity is negatively regulated by its SH3 domain; deletion of this domain converts c-Abl into an oncogene.
• CDC2-mediated phosphorylation regulates the DNA-binding activity of ABL1, suggesting a role in the cell cycle.
• In chronic myelogenous leukemia and some acute lymphoblastic leukemias, a (9;22) translocation produces the Philadelphia chromosome, fusing c-Abl from chromosome 9 with the Bcr gene on chromosome 22.
• c-Abl was first identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV).
• It may regulate DNA repair by triggering apoptosis when DNA damage is irreparable.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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