Thermo Fisher Scientific Parkin Polyclonal Antibody
Parkin 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot, IHC, IP에 사용 가능. Human 및 Rat 반응성. 항원 친화 크로마토그래피로 정제되었으며, -20°C에서 보관. 파킨슨병 관련 연구에 적합.
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | 1.0 µg/mL | - |
| Immunoprecipitation (IP) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic Peptide: C I(298) K E L H H F R I L G E E Q Y N(313) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2160094 |
Product Specific Information
PA1-751 detects recombinant human parkin.
PA1-751 has been successfully used in Western blot and immunohistochemical procedures.
By Western blot, this antibody detects an ~52 kDa protein representing recombinant human parkin.
The PA1-751 immunizing peptide corresponds to amino acid residues 298–313 from human parkin.
This sequence is completely conserved between human, mouse, and rat.
PA1-751 immunizing peptide (Cat. # PEP-159) is available for use in neutralization and control experiments.
Target Information
The precise function of the Parkin gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation.
Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease.
Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms.
Additional splice variants of this gene have been described but currently lack transcript support.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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